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After a quick breach for the Thanksgiving holiday, the IPO bazaar is accessible to bounce aback into action abutting anniversary with several deals slated to price. This three anniversary amplitude from the end of November through mid-December is frequently one of the busiest times of the year as companies and advance banks attending to barrage IPOs afore year-end. As far as abutting weeks IPOs go, the action akin may be rather aerial as they mainly abide of abate banking casework companies and barren pharmaceuticals. However, that does not beggarly that none of them will end up actuality absolutely acknowledged as a cardinal of clinical-stage pharmaceuticals accept become big winners this year. 

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Lead UnderwritersCredit Suisse, Jefferies, Stephens

Shares Offered6.7 M

Expected Amount Range$14-$16

Expected Deal Size$100.0 M

Net Sales/Growth*$470.1M/ 9%

Net Inc*


*Nine months concluded September 30, 2017

Lead UnderwritersGoldman Sachs, Jefferies

Shares Offered5.9 M

 Expected Amount Range$24-$27

Expected Deal Size$149.9 M

Net Sales*$0

Net Loss*


*9-Months Concluded September 30, 2017

Odonate (ODT) is a biologic aggregation developing assay for bodies with cancer. Its antecedent focus is on the development of tesetaxel, a atypical chemotherapy abettor that belongs to a chic of drugs accepted as taxanes, which are broadly acclimated in the assay of cancer.

• Tesetaxel has several abeyant advantages over currently accessible taxanes, including: articulate administering with a low bolus accountability and a patient-friendly dosing regimen; a conception that does not accommodate solubilizing agents that are accepted to account hypersensitivity (allergic) reactions; and bigger action adjoin chemotherapy-resistant tumors.

• Tesetaxel has been about able-bodied acceptable in analytic studies and has accustomed able-bodied single-agent antitumor action in two Phase 2 studies in patients with locally avant-garde or metastatic breast blight (MBC). Odonate expects to activate enrolling patients in Phase 3 studies in MBC, accepted as CONTESSA, in 4Q17 and address top-line after-effects from this abstraction in 2020.

• The ambition for tesetaxel is to advance an able chemotherapy best for patients that provides quality-of-life advantages over accepted alternatives.

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• Breast blight is the second-most accepted blight worldwide, with an estimated 1.8 mln new cases diagnosed per year. In the US, an estimated 255,000 new cases are diagnosed and about 41,000 women will die of the ache anniversary year, authoritative it the second-leading account of blight afterlife in women.

• Breast blight about is staged (Stage 0-IV) based on the admeasurement of the tumor, whether or not the bump is invasive, whether or not the blight is in the lymph nodes, and whether or not the blight has advance (metastasized) to added genitalia of the anatomy above the breast.

• For best patients diagnosed with aboriginal breast blight who abide surgical treatment, the cast is good; the 5-year adaptation amount for these patients is about 94%. However, the cast for patients with MBC (which includes patients who relapsed afterward anaplasty as able-bodied as patients who are busted aloft antecedent diagnosis) charcoal poor; the 5-year adaptation amount for metastatic ache is about 22%, authoritative MBC an breadth of continued, aerial unmet medical need.

• Paclitaxel, the best frequently acclimated taxane in the assay of MBC, is formulated with a solubilizing abettor accepted to account hypersensitivity reactions, is associated with cogent ancillary furnishings such as alopecia (hair loss) and borderline neuropathy (weakness, asleep and/or affliction from accident to the nerves), and, like all currently accessible taxanes, charge be administered intravenously, about at an beverage center. These beverage centermost visits about are appropriate account and are several hours in duration.

• There is additionally capecitabine, which is orally administered and accordingly offers quality-of-life advantages over IV-delivered chemotherapies. However, capecitabine requires a ample bolus accountability and a arduous dosing schedule. Thus, there is a charge for new agents that, back accustomed abandoned or in accumulated with added agents, accept able-bodied antitumor action and are bigger acceptable and easier to take.

• Tesetaxel retains the aforementioned taxane amount as the accustomed taxanes, but is chemically advised to: be awful orally bioavailable; accept a continued abolishment half-life; be awful soluble; and absorb action adjoin chemotherapy-resistant bump cells. Odonate believes that tesetaxel’s different backdrop may construe into cogent allowances for patients: 1) Articulate administering with a low bolus accountability and a patient-friendly dosing regimen; 2) a conception that does not accommodate solubilizing agents independent in added taxane formulations accepted to account hypersensitivity reactions; and 3) abiding antitumor activity.

• Odonate believes that an all-oral regimen, such as tesetaxel monotherapy or tesetaxel added capecitabine, that may adjournment the charge to accept intravenous chemotherapy in an beverage centermost will be adopted by patients.

• As with the case with best analytic date pharma names, Odonate does not absolutely accept any financials at this point. It’s years abroad from profitability, if ever, and it has never generated any revenue.

Lead UnderwritersJP Morgan, Leerink Partners

Shares Offered3.3 M

 Expected Amount Range$14-$16

Expected Deal Size$125.0 M

Revenue/Growth*$16.3M/ 50%

Operating Loss*

 ($18.9) M

Cash & Equivalents (P/F)*

Quanterix is a activity sciences aggregation that has developed an ultra-sensitive agenda immunoassay belvedere that advances attention bloom for activity sciences assay and diagnostics. The company’s belvedere enables barter to anxiously ascertain protein biomarkers in acutely low concentrations in blood, serum and added fluids that, in abounding cases, are ephemeral application conventional, analog immunoassay technologies. In accession to enabling new applications and insights in protein analysis, Quanterix is additionally developing their Simoa technology to ascertain nucleic acids in biological samples.

Simoa decidedly advances ELISA technology, which has been the industry accepted for protein apprehension for over forty years, through its adeptness to allurement distinct molecules in tiny microwells that are 2.5 bln times abate than acceptable ELISA wells, acceptance for an assay and agenda readout of anniversary alone molecule, which is not accessible with accepted ELISA technology. Quanterix currently sells its Simoa articles for assay use only, but intends to aggrandize into the analytic and attention bloom screening markets.

Quanterix’s Simoa technology has applications above the activity science research, affection and attention bloom screening markets. Their antecedent ambition bazaar has been the activity science assay market, and all of their artefact and account acquirement to date has been in this market. Citing estimates from the Third-Party Assay Report, Quanterix believes that the absolute analytic and attention bloom screening markets addressable by the aggregation and others application Simoa accept the abeyant to ability an accumulated of $30 billion per year.


For the aboriginal nine months of 2017, the aggregation appear revenues of $16.29 mln, up 49.3% y/y. For reference, revenues grew 44.4% in 2016 to $17.59 mln. Gross margins bigger to 43.6% for the aboriginal nine months of 2017 from 38.1% in the year beforehand period. Net accident for the aboriginal nine months of 2017 widened, however, to $19.64 mln from $14.9 mln in the year beforehand aeon as absolute operating costs added 36.4% to $35.2 mln.

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As of September 30, the aggregation appear $18.69 mln in banknote and banknote equivalents, and $9.33 mln in abiding debt.


The aggregation is planning to action 3.34 mln shares at a amount amid $14.00-16.00. Assertive of Quanterix’s absolute stockholders accept adumbrated an absorption in purchasing an accumulated of up to about $30 mln of shares of accepted banal in the alms at the antecedent accessible alms price.

Quanterix expects net gain of about $43.9 mln from the IPO. They plan to use the gain from this alms to aggrandize their activity sciences bartering operations to abound and abutment the installed abject of their articles amid activity sciences assay barter in the United States and internationally, to advance and amend their Simoa technology and instruments and to advance added assays, including assays for nucleic acerbic detection, and to abutment the barrage of their new Quanterix SR-X instrument, currently appointed for barrage in 2018.

Quanterix believes that the net gain from this offering, calm with banknote generated from bartering sales and absolute banknote and banknote equivalents as of September 30, 2017, excluding any approaching accessible borrowings beneath their debt facility, will accredit them to armamentarium operating costs and basic amount requirements for at atomic the abutting 24 months.


Quanterix competes with both accustomed and development-stage activity science companies that design, accomplish and bazaar instruments for protein detection, nucleic acerbic apprehension and added applications. Companies such as Bio-Techne, Luminex, MesoScale Diagnostics, Singulex, Gyros, and Nanostring Technologies accept articles for protein apprehension that attempt in assertive segments of the bazaar in which Quanterix sells its products. Additionally, as the aggregation or its ally aggrandize the applications for their articles to accommodate affection and attention bloom screening, they apprehend to attempt with companies such as Siemens, Abbott, Roche, Ortho Analytic Affection and Thermo Fisher Scientific.

The aggregation has activated to account its accepted banal on The Nasdaq Global Bazaar beneath the attribute “QTRX.”

Lead UnderwritersGoldman Sachs, Morgan Stanley, JP Morgan

Shares Offered8.3 M

 Expected Amount Range$17-$19

Expected Deal Size$150.0 M

Net Sales*$0

Operating Loss*

 ($66.6) M

Cash & Equivalents*$356.7 M

*3 Months Concluded Sept. 30, 2017

Lead UnderwritersKeefe, Bruyette & Woods, Sandler O’Neill, Piper Jaffray

Shares Offered11.4 M

 Expected Amount Range$10.50-$12.50

Expected Deal Size$130.5 M

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Net Int Inc*$83.4M/18%

Net Income*

 $49.0 M

Total Assets*$5.3 B

*3 Months Concluded Sept. 30, 2017

Business Overview:

Luther Burbank is a California-based coffer captivation aggregation for Luther Burbank Savings, a California accountant bank.

The coffer specializes in absolute acreage anchored lending in city areas forth the West Coast with a focus on multifamily residential lending and jumbo, adverse distinct ancestors residential lending. Management believes the bank’s success depends on a development of able relationships with depositors.

The bank’s archetypal multifamily borrower is a able broker with assorted backdrop and a focus on advance in counterbalanced cash-flowing assets to body equity, accepted income, and wealth. The bank’s own bankers arise the aggregate of multifamily loans, but some originations are additionally fabricated through brokers.

The coffer has nine locations in California. Four branches are amid in the San Francisco breadth while the actual bristles are amid in the Los Angeles area. Going forward, the coffer affairs to aggrandize into added markets on the West Coast with an ultimate ambition of accepting a attendance in cities amid Seattle and San Diego.

|Use of Proceeds:

The coffer intends to use $40 actor to armamentarium a banknote administration to shareholders anon afterwards closing of the offering. This allotment will not be paid to new investors. Actual gain will be acclimated to access the bank’s basic and for alive basic & added accepted accumulated purposes.

Financials and Distribution:

The coffer accomplished a 12.9% admixture anniversary asset advance amount amid December 31, 2014 and December 31, 2016. Earnings during the aforementioned aeon added at a admixture anniversary advance amount of 22.7%. Loans during the two-year aeon added at a admixture boilerplate advance amount of 13.9%.57.0% of the bank’s accommodation portfolio at the end of September 2017 was fabricated up of multifamily residential loans while distinct ancestors residential loans fabricated up 40.0% of the total. Bartering absolute acreage loans and architecture & acreage development loans fabricated up 2.0% and 1.0% of the accommodation portfolio, respectively.

At the end of September 2017, distinct ancestors loans had an boilerplate antithesis of $840,000 with a abounding boilerplate accommodation to amount of 65.0% and a abounding boilerplate acclaim account at origination/refreshed of 746. Multi-family loans had an boilerplate antithesis of $1.40 actor with a abounding boilerplate accommodation to amount arrangement of 56.0% and a abounding boilerplate debt account advantage arrangement of 1.57.

At the end of September, nonperforming assets fabricated up 0.11% of the bank’s absolute assets. The coffer bankrupt on aloof one acreage back January 1, 2015. The coffer generated net absorption assets of $83.43 actor through the aboriginal nine months of 2017, which was up 18.4% year-over-year. During 2016, the bank’s net absorption assets totaled $94.64 million, which represented year-over-year advance of 11.5%.

Net assets for the aboriginal nine months of 2017 was $48.96 million, up 26.1% year-over-year. Net assets in 2016 totaled $52.12 million, up 47.3% year-over-year. The coffer becoming $0.70 per allotment during the nine months concluded September 30, 2017, up from $0.56 for the aboriginal nine months of 2016. The coffer becoming $0.74 during budgetary year 2016, up from $0.51 per allotment becoming in 2015.

Starting in the added division of 2018, the coffer affairs to authorize a annual banknote allotment of $0.0575.


In this area of our account column, we accommodate a rolling account of anniversary IPO to amount over the accomplished few months. Additionally, achievement measures will be included in the table, as able-bodied as our brand or affect reading, if applicable. 

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